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Ammonia → 6-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydro-isoquinoline-4-carboxylic acid piperidin-4-ylamide

HRID 907285
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반응식

HRID 907285 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:27]4[CH:32]=[C:31]([C:33](=[O:38])[NH:34][CH:35]5[CH2:37][CH2:36]5)[CH:30]=[CH:29][C:28]=4[CH3:39])[CH:25]=3)[C:20](=[O:40])[N:19]([CH2:41][C:42]3[CH:47]=[CH:46][N:45]=[CH:44][CH:43]=3)[CH:18]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O.N>ClCCl>[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:27]4[CH:32]=[C:31]([C:33](=[O:38])[NH:34][CH:35]5[CH2:36][CH2:37]5)[CH:30]=[CH:29][C:28]=4[CH3:39])[CH:25]=3)[C:20](=[O:40])[N:19]([CH2:41][C:42]3[CH:47]=[CH:46][N:45]=[CH:44][CH:43]=3)[CH:18]=2)=[O:16])[CH2:10][CH2:9]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 6422Trifluoroacetic acidHCID 575517434-{[6-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydro-isoquinoline-4-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 250205606-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydro-isoquinoline-4-carboxylic acid piperidin-4-ylamide

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

To a solution of the product of step i) (0.1 g) in dichloromethane (9 mL) was added trifluoroacetic acid (1 mL) and the mixture stirred at room temperature for 1 hour. The reaction was basified by the addition of 0.88 ammonia and washed with water. The organics were dried over magnesium sulphate, filtered and concentrated to dryness to yield the title compound as a solid (0.08 g).

후처리

  1. washwashed with water
  2. dry with materialThe organics were dried over magnesium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-b3c455767a294e62a6951e1b0663eff1
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08012979B2

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