Sodium Carbonate → (-)-Galantamine

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The resulting 88% galanthamine hydrobromide is suspended in 7.6 l of water. The suspension is cooled to 0° C. and diluted, keeping the temperature from 0 to 5° C., with 5.2 l of 10% sodium carbonate. Five extractions with 5 l of n-butyl acetate are obtained, the organic phases are pooled and washed with 2.5 l of salted water. The organic phases are concentrated under vacuum to a volume of 4 l and allowed to crystallize at room temperature. The crystals are filtered and dried under vacuum at 70° C. 1.2 kg of galanthamine are obtained with chemical-physical and spectroscopical characteristics consistent with those reported in the literature (P. Carroll et al., Bull. Soc. Chim. Fr. (1990), 127, 769).

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