Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluoroaniline → N-(3-fluorophenyl)-2-(4-methoxyphenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluoroaniline | HCID 9742 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Methyl 4-methoxyphenylacetate | HCID 90266 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | N-(3-fluorophenyl)-2-(4-methoxyphenyl)acetamide | HCID 765698 | — |
반응 단계
Using the procedure for Example 22, (4-methoxy-phenyl)-acetic acid methyl ester Compound 22a was reacted with 3-fluoro-phenylamine and sodium hydride in DMSO at room temperature to provide N-(3-fluoro-phenyl)-2-(4-methoxy-phenyl)-acetamide Compound 23a. Compound 23a was reacted with borotribromide in dichloromethane to yield N-(3-fluoro-phenyl)-2-(4-hydroxy-phenyl)-acetamide Compound 23b.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08013153B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-84b4df770f5e40fc9d42806e5fcdafab |
| 출처 메모 | uspto-grants-2011_09 |