Borane → 2-(1-Piperazinyl)benzyl alcohol

HRID 907578노트

반응식

HRID 907578 반응식
S(=O)(=O)(O)O.[N:6]1([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14](O)=[O:15])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.B>O1CCCC1.CO>[N:6]1([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[CH2:14][OH:15])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1

참가 물질

5

반응물 2

HCID 6331BoraneHCID 673880502-Piperazin-1-yl-benzoic acid sulfuric acid salt

생성물 1

HCID 220780362-(1-Piperazinyl)benzyl alcohol

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매2회

실험 절차

2-piperazin-1-yl-benzoic acid sulfuric acid salt (˜10 mmol) was suspended in 50 mL of tetrahydrofuran. Then 100 mL of 1.0 M borane in tetrahydrofuran (100 mmol) was added and the reaction was stirred at room temperature overnight with a bubbler attached to release pressure in the flask. The reaction mixture was diluted with 50 mL of methanol. The reduced product (470 mg) crystallized out of the mixture during evaporation.

후처리

  1. customThe reduced product (470 mg) crystallized out of the mixture during evaporation

출처 및 근거

ORD 기록
ord-8364e2160a8e400b860f1ad26cced702
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013156B2

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