Dimethylamine → [[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-(3-phenoxy-phenyl)-methyl]-amine

HRID 9078

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10](C)[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:5]=[CH:6][C:7]=1[F:8].[Cl-].[O:20]([C:27]1[CH:28]=[C:29]([CH:34]=[CH:35][CH:36]=1)[CH:30]=[N+:31](C)C)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.O(C1C=C(C=CC=1)C=O)C1C=CC=CC=1.CNC>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:30]([NH2:31])[C:29]2[CH:34]=[CH:35][CH:36]=[C:27]([O:20][C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:28]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

반응물 4

HCID 674Dimethylamine

HCID 382843-Phenoxybenzaldehyde

HCID 219853262-(3-Chloro-4-fluorophenyl)-1-methylindole

HCID 21985375(3-Phenoxy-benzylidene)-dimethylammonium chloride

생성물 1

HCID 69667101[[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-(3-phenoxy-phenyl)-methyl]-amine

실험 절차

The preparation was carried out in accordance with general synthesis instructions 4 from 2-(3-chloro-4-fluoro-phenyl)-methyl-1H-indole and (3-phenoxy-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 3-phenoxy-benzaldehyde and dimethylamine.

출처 및 근거

ORD 기록: ord-a3acf54bec8b45b7a82a1278ef642df9
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07091220B2

연결된 노트

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