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1,3-Thiazole-5-carbaldehyde → Methyl 4-oxo-2-phenyl-3-(thiazol-5-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

HRID 907852
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HRID 907852 반응식
[S:1]1[C:5]([CH:6]=O)=[CH:4][N:3]=[CH:2]1.[CH:8](=[N:15]/[C:16]1[CH:24]=[CH:23][CH:22]=[C:21]2[C:17]=1[CH2:18][O:19][C:20]2=[O:25])\[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:26][O-:27].[Na+]>C(OCC)(=O)CC>[O:27]=[C:26]1[C:17]2[C:21]([C:20]([O:19][CH3:18])=[O:25])=[CH:22][CH:23]=[CH:24][C:16]=2[NH:15][CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]1[C:5]1[S:1][CH:2]=[N:3][CH:4]=1
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참가 물질

5

반응물 3

HCID 27735771,3-Thiazole-5-carbaldehydeHCID 10942334Sodium MethoxideHCID 178519069HCID 178519069, 화합물

생성물 1

HCID 67258775Methyl 4-oxo-2-phenyl-3-(thiazol-5-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate수율 7.5%

시약·촉매·용매 1

HCID 7749Ethyl Propionate용매

실험 절차

A mixture of thiazole-5-carbaldehyde (500 mg, 4 mmol), (E)-4-(benzylideneamino)isobenzofuran-1(3H)-one (960 mg, 4 mmol), sodium methanolate (375 mg, 16.1 mmol) and ethyl propionate (30 mL) were stirred at room temperature overnight. Then the resulting mixture was evaporated under reduced pressure and extracted with ethyl acetate (4×100 mL) and concentrated. The crude product was purified by column chromatography (silica gel, petroleum ether:ethyl acetate 10:1 to 1:1) to give methyl 4-oxo-2-phenyl-3-(thiazol-5-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate (110 mg, yield 7%). LC-MS (ESI) m/z: 379 (M+1)+.

후처리

  1. customThen the resulting mixture was evaporated under reduced pressure
  2. extractionextracted with ethyl acetate (4×100 mL)
  3. concentrationconcentrated
  4. customThe crude product was purified by column chromatography (silica gel, petroleum ether:ethyl acetate 10:1 to 1:1)

출처 및 근거

ORD 기록
ord-d05fe45c92814e21b1d934e97957fe49
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08012976B2

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