C(=O)([O-])[O-].[Cs+].[Cs+].C[C:8]1[S:12][C:11]([NH2:13])=[N:10][N:9]=1.Cl[C:15]1[S:16][C:17]([C:21]2[CH:26]=[CH:25][C:24]([S:27]([NH2:30])(=[O:29])=[O:28])=[CH:23][CH:22]=2)=[C:18]([CH3:20])[N:19]=1.C(OCC)(=O)C.CO>CC(N(C)C)=O>[CH3:20][C:18]1[N:19]=[C:15]([NH:13][C:11]2[S:12][CH:8]=[N:9][N:10]=2)[S:16][C:17]=1[C:21]1[CH:22]=[CH:23][C:24]([S:27]([NH2:30])(=[O:29])=[O:28])=[CH:25][CH:26]=1Caesium carbonate (0.08 g, 0.24 mmol) and 5-methyl-[1,3,4]thiadiazol-2-ylamine (0.031 g, 0.27 mmol) are added to a solution of 4-(2-chloro-4-methyl-thiazol-5-yl)-benzenesulfonamide (25d) (0.07 g, 0.24 mmol) in dimethylacetamide (2 ml). The mixture is heated with stirring at 110° C. for 18 hours. After adding more 5-methyl-[1,3,4]thiadiazol-2-ylamine (0.056 g, 0.49 mmol) heating is continued at 130° C. for an additional 8 hours. The solvent is removed and the product is purified by chromatography on silica eluting with ethyl acetate to give an orange solid. Trituration with ethyl acetate-methanol affords the title compound as a yellow solid (0.0081 g)
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