N-Pyrazinylthiourea → [4-Methyl-5-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-pyrazin-2-yl-amine
반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=O)[CH3:11])=[CH:5][CH:4]=1.[N:13]1[CH:18]=[CH:17][N:16]=[CH:15][C:14]=1[NH:19][C:20]([NH2:22])=[S:21].CC1N=C(NC2C=NC=CN=2)SC=1C1C=CC(S(N)(=O)=O)=CC=1>>[CH3:11][C:10]1[N:22]=[C:20]([NH:19][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][N:13]=2)[S:21][C:9]=1[C:6]1[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[CH:4][CH:5]=1참가 물질
4
실험 절차
Using 1-(4-methylsulfanyl-phenyl)-propan-2-one (27b) and pyrazin-2-yl-thiourea (1a) in an analogous procedure described for the preparation of 4-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide (Example 1b) affords the title compound.
출처 및 근거
- ORD 기록
- ord-ed82468d7a0d4038958b8e9bc35da95d
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08017608B2
반응 노트
불러오는 중…