4-(Methylthio)benzaldehyde → [5-(3-Chloro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-pyridin-3-yl-amine
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[S:10]([CH3:13])(=[O:12])=[O:11])[CH:5]=O.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][C:21]([NH2:23])=[S:22])[CH:15]=1.[CH3:24][C:25]1N=C(NC2C=NC=CN=2)SC=1C1C=CC(SC)=CC=1.CSC1C=CC(C=O)=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[S:22][C:21]([NH:20][C:16]3[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=3)=[N:23][C:24]=2[CH3:25])[CH:7]=[CH:8][C:9]=1[S:10]([CH3:13])(=[O:12])=[O:11]참가 물질
5
반응물 4
생성물 1
실험 절차
The title compound is prepared starting from 3-chloro-4-methanesulfonyl-benzaldehyde (prepared as described in WO 01/49660 A1) and 3-pyridylthiourea following an analogous sequence of reactions described for the preparation of [4-Methyl-5-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-pyrazin-2-yl-amine (27c) from 4-methylsulfanyl-benzaldehyde.