2-Chloro-5-(2-oxo-propyl)-benzenesulfonamide → 5-(1-Bromo-2-oxo-propyl)-2-chloro-benzenesulfonamide
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[S:12]([NH2:15])(=[O:14])=[O:13].C1C=C[NH+]=CC=1.[Br:22][Br-]Br>C1COCC1>[Br:22][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([S:12]([NH2:15])(=[O:14])=[O:13])[CH:4]=1)[C:9](=[O:11])[CH3:10]참가 물질
3
실험 절차
A stirred solution of 2-chloro-5-(2-oxo-propyl)-benzenesulfonamide (33a) (1.4 g, 5.7 mmol) in dry THF (100 ml) at room temperature is treated with polymer supported pyridine hydrobromide perbromide (2.9 g, 5.7 mmol) and left to stir overnight. The reaction mixture is then filtered and the solvent removed in vacuo. The residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane to give the titled compound.
후처리
- waitleft
- filtrationThe reaction mixture is then filtered
- customthe solvent removed in vacuo
- customThe residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane
출처 및 근거
- ORD 기록
- ord-fa16fbc243584ccc954fa7c37f7cfb21
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08017608B2
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