6-Chloropyrazin-2-ylthiourea → (6-Chloro-pyrazin-2-yl)-[5-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-amine

HRID 908196노트

반응식

HRID 908196 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12](=O)[CH3:13])=[CH:7][C:6]=1[C:15]([F:18])([F:17])[F:16])(=[O:4])=[O:3].[Cl:19][C:20]1[N:25]=[C:24]([NH:26][C:27]([NH2:29])=[S:28])[CH:23]=[N:22][CH:21]=1>>[Cl:19][C:20]1[N:25]=[C:24]([NH:26][C:27]2[S:28][C:11]([C:8]3[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[C:6]([C:15]([F:18])([F:17])[F:16])[CH:7]=3)=[C:12]([CH3:13])[N:29]=2)[CH:23]=[N:22][CH:21]=1

참가 물질

3

반응물 2

HCID 144606806-Chloropyrazin-2-ylthioureaHCID 673910181-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-propan-2-one

생성물 1

HCID 86761404(6-Chloro-pyrazin-2-yl)-[5-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-amine

실험 절차

The titled compound is prepared from 1-(4-methanesulfonyl-3-trifluoromethyl-phenyl) propan-2-one (59c) and 6-chloro-pyrazin-2-yl-thiourea.

출처 및 근거

ORD 기록
ord-de2ec74ff78648d1a0c0c4744b09383a
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017608B2

반응 노트

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