Water → Methyl 6-bromo-2-phenylimidazo[1,2-a]pyridine-7-carboxylate

HRID 908219노트

반응식

HRID 908219 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.C([O-])(O)=O.[Na+].[NH2:16][C:17]1[CH:18]=[C:19]([C:24]([Br:27])=[CH:25][N:26]=1)[C:20]([O:22][CH3:23])=[O:21].O>CO>[CH3:23][O:22][C:20]([C:19]1[C:24]([Br:27])=[CH:25][N:26]2[CH:2]=[C:3]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:16]=[C:17]2[CH:18]=1)=[O:21]

참가 물질

6

반응물 4

HCID 962WaterHCID 6259Phenacyl bromideHCID 516892Sodium BicarbonateHCID 25307230Methyl 2-amino-5-bromoisonicotinate

생성물 1

HCID 67041599Methyl 6-bromo-2-phenylimidazo[1,2-a]pyridine-7-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Bromoacetophenone (17.29 g, 87 mmol) and NaHCO3 (8.03 g, 96 mmol) were added to a solution of methyl 2-amino-5-bromoisonicotinate (20.07 g, 87 mmol) in methanol (240 ml), and the mixture was heated to reflux (5 h). After cooling to r.t., water (75 ml) was added, and the brown suspension was stirred (15 min) and filtered. The precipitate was washed with a small amount of methanol. The title compound (10.11 g, 35%) was dried under vacuum and was used in the next step without further purification.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux (5 h)
  3. filtrationfiltered
  4. washThe precipitate was washed with a small amount of methanol
  5. dry with materialThe title compound (10.11 g, 35%) was dried under vacuum
  6. customwas used in the next step without further purification

출처 및 근거

ORD 기록
ord-d3b91ad9ce8b47729249315fd3d39a4b
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017604B2

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