Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Phenylimidazo[1,2-c]pyrimidin-7-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phenacyl bromide | HCID 6259 | — |
| 반응물 | Pyrimidine-4,6-diamine | HCID 79608 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Phenylimidazo[1,2-c]pyrimidin-7-amine | HCID 404051 | — |
반응 단계
ω-Bromoacetophenone (9.04 g, 45 mmol) and NaHCO3 (4.30 g, 50 mmol) were added to a solution of 4,6-diaminopyrimidine (5.00 g, 0.45 mmol) in methanol (80 ml), and the mixture was heated to reflux (3 h). Upon cooling, water (40 ml) was added, and the suspension was stirred at r.t. (15 min). The precipitated title compound (5.62 g, 59%) was isolated by filtration, washed with small amounts of water and methanol, and dried under vacuum. MS (m/e)=211.1 [M+H+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08017604B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-977e643049e748a8ae969dd88ddb423f |
| 출처 메모 | uspto-grants-2011_09 |