Sodium Acetate → 3,5-Difluorotoluene

HRID 908241노트

반응식

HRID 908241 반응식
Br[CH2:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[C:5]([F:10])[CH:4]=1.C([O-])(=O)C.[Na+]>CCOCC.[Pd]>[F:9][C:7]1[CH:8]=[C:3]([CH3:2])[CH:4]=[C:5]([F:10])[CH:6]=1

참가 물질

5

반응물 2

HCID 517045Sodium AcetateHCID 5188963,5-Difluorobenzyl bromide

생성물 1

HCID 27783293,5-Difluorotoluene

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 1-(bromomethyl)-3,5-difluorobenzene (50 g, 0.24 mol), 10% Pd/C (3 g) and sodium acetate (140 g, 1.7 mol) in anhydrous ether (250 mL) was stirred under hydrogen at atmospheric pressure for 24 hr. The mixture was filtered and the filtrate was dried over anhydrous Na2SO4, filtered and used directly in the next step. 1H-NMR (500 MHz, CDCl3): δ 6.56 (d, 2H, J=6.0 Hz), 6.47 (t, 1H, J=9.0 Hz), 2.22 (s, 3H).

후처리

  1. filtrationThe mixture was filtered
  2. dry with materialthe filtrate was dried over anhydrous Na2SO4
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-142d52581a6f4ee5a4b9467cfba32377
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017605B2

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