Dimethylamine → HCID 59262855, 화합물

HRID 908358노트

반응식

HRID 908358 반응식
CS[C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5]2[CH2:10][CH2:11][CH2:12][C:13](=[O:14])[C:4]=12.[CH3:15][NH:16][CH3:17]>C1COCC1>[CH3:15][N:16]([CH3:17])[C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5]2[CH2:10][CH2:11][CH2:12][C:13](=[O:14])[C:4]=12

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 27787593-(Methylthio)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbonitrile

생성물 1

HCID 59262855HCID 59262855, 화합물수율 45%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carbonitrile (0.446 g) and dimethylamine (excess) in THF were heated in a sealed tube at 80° C. for 10 days. Aqueous work up and chromatographic purification afforded 0.2 g of 3-dimethylamino-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carbonitrile (45%).

후처리

  1. customAqueous work up and chromatographic purification

출처 및 근거

ORD 기록
ord-9bd9c79ec7f646828492ff414cb0a676
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017619B2

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