Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride → 5-Hydroxypentyl benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Dimethyltin dichloride | HCID 12955 | — |
| 반응물 | Pentane-1,1-diol | HCID 17775877 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Hydroxypentyl benzoate | HCID 569873 | — |
반응 단계
To a solution of pentanediol (1 mmol) in THF (5 ml) was added a catalytic amount of dimethyltin dichloride (0.01 mmol), solid K2CO3 (2.0 mmol) and benzoyl chloride (1.2 mmol), at room temperature. After stirring the mixture at room temperature until the diol disappeared (checked by TLC), the mixture was poured onto water and the organic portion was extracted with DCM. After evaporation of the solvent, a residue was obtained and purified by flash chromatography using a mixture of DCM/MeOH as eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08017620B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-12439db56bd543eb8c929760e1c87312 |
| 출처 메모 | uspto-grants-2011_09 |