Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorotrimethylsilane | HCID 6397 | — |
| 반응물 | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide | HCID 11538331 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide hydrochloride | HCID 11538330 | 52% |
반응 단계
2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide (266 mg, 0.755 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.139 ml, 1.1 mmol) was added. After 2.5 h the hydrochloride was isolated as a colourless solid in a yield of 52% (152 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08017630B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-78bb9bef1af44779ac8b2aa8182f185e |
| 출처 메모 | uspto-grants-2011_09 |