Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide hydrochloride

HRID 908938

반응식

HRID 908938 반응식
[CH3:1][N:2]([CH3:31])[C:3]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[NH:18][CH:17]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:32][Si](C)(C)C>CC(CC)=O>[ClH:32].[CH3:31][N:2]([CH3:1])[C:3]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:4][CH2:5][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[NH:18][CH:17]=2)=[O:11])[CH2:7][CH2:8]1

참가 물질

4

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 116553572-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide

생성물 1

HCID 116553562-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide hydrochloride수율 75%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide (742 mg, 1.78 mmol) was dissolved in ethyl methyl ketone (25 ml), and chlorotrimethylsilane (0.34 ml, 2.7 mmol) was added. After 2 h the hydrochloride was isolated as a beige-coloured solid with an m.p. of 165-173° C. in a yield of 75% (606 mg).

출처 및 근거

ORD 기록
ord-516b9981565a4fe4bea2f094ca775f56
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017630B2

연결된 노트

불러오는 중…