Chlorotrimethylsilane → HCID 11647293, 화합물

HRID 908953노트

반응식

HRID 908953 반응식
[CH3:1][N:2]([CH3:28])[C:3]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:29][Si](C)(C)C>CC(CC)=O>[ClH:29].[CH3:28][N:2]([CH3:1])[C:3]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:4][CH2:5][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:11])[CH2:7][CH2:8]1

참가 물질

4

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 11647294HCID 11647294, 화합물

생성물 1

HCID 11647293HCID 11647293, 화합물수율 86%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

2-(4-Dimethylamino-4-pyridin-2-ylcyclohexylidene)-N-(3-phenylpropyl)acetamide (203 mg, 0.537 mmol was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.2 ml, 1.6 mmol) was added. After 1.5 h the hydrochloride was isolated as a colourless solid with an m.p. of 173-176° C. in a yield of 86% (190 mg).

출처 및 근거

ORD 기록
ord-475d83147ea0453aaf8beab261a5a97f
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017630B2

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