Ethoxyacetyl chloride → N-{7-bromo-4-[(2-hydroxy-2-methylpropyl)amino][1,5]naphthyridin-3-yl}-2-ethoxyacetamide hydrochloride

HRID 909360노트

반응식

HRID 909360 반응식
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH2:13][C:14]([CH3:17])([OH:16])[CH3:15])=[N:9][CH:8]=[C:7]([Br:18])[CH:6]=2.[CH2:19]([O:21][CH2:22][C:23]([Cl:25])=[O:24])[CH3:20]>C(#N)C>[ClH:25].[Br:18][C:7]1[CH:6]=[C:5]2[C:10]([C:11]([NH:12][CH2:13][C:14]([OH:16])([CH3:15])[CH3:17])=[C:2]([NH:1][C:23](=[O:24])[CH2:22][O:21][CH2:19][CH3:20])[CH:3]=[N:4]2)=[N:9][CH:8]=1

참가 물질

4

반응물 2

HCID 84189Ethoxyacetyl chlorideHCID 670523831-[(3-Amino-7-bromo[1,5]naphthyridin-4-yl)amino]-2-methylpropan-2-ol

생성물 1

HCID 67052474N-{7-bromo-4-[(2-hydroxy-2-methylpropyl)amino][1,5]naphthyridin-3-yl}-2-ethoxyacetamide hydrochloride수율 81.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-[(3-amino-7-bromo[1,5]naphthyridin-4-yl)amino]-2-methylpropan-2-ol (100.0 g, 321.4 mmol) and acetonitrile (1 L) was stirred for five minutes, and ethoxyacetyl chloride (43.3 g, 353.3 mmol) was added. The reaction was stirred overnight at room temperature. The solid product was isolated by filtration and washed with acetonitrile (200 mL) to provide 113 g of N-{7-bromo-4-[(2-hydroxy-2-methylpropyl)amino][1,5]naphthyridin-3-yl}-2-ethoxyacetamide hydrochloride as a yellow solid.

후처리

  1. stirringThe reaction was stirred overnight at room temperature
  2. customThe solid product was isolated by filtration
  3. washwashed with acetonitrile (200 mL)

출처 및 근거

ORD 기록
ord-b3f25160018946ac9b2124effa2f8dbe
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017779B2

반응 노트

불러오는 중…