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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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3-Bromo-5-ethoxy-4-hydroxybenzaldehyde → 4-(3-Bromo-5-ethoxy-4-hydroxy-phenyl)-2-methyl-3-nitro-7-propyl-4,6,7,8-tetra-hydro-1H-quinolin-5-one

HRID 909388
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HRID 909388 반응식
[CH3:1][C:2]([NH2:7])=[CH:3][N+:4]([O-:6])=[O:5].[CH2:8]([CH:11]1[CH2:16][C:15](=[O:17])[CH2:14][C:13](=O)[CH2:12]1)[CH2:9][CH3:10].[Br:19][C:20]1[CH:21]=[C:22]([CH:25]=[C:26]([O:29][CH2:30][CH3:31])[C:27]=1[OH:28])[CH:23]=O>C(O)C>[Br:19][C:20]1[CH:21]=[C:22]([CH:23]2[C:14]3[C:15](=[O:17])[CH2:16][CH:11]([CH2:8][CH2:9][CH3:10])[CH2:12][C:13]=3[NH:7][C:2]([CH3:1])=[C:3]2[N+:4]([O-:6])=[O:5])[CH:25]=[C:26]([O:29][CH2:30][CH3:31])[C:27]=1[OH:28]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6124963-Bromo-5-ethoxy-4-hydroxybenzaldehydeHCID 27372245-Propylcyclohexane-1,3-dioneHCID 714047121-Nitroprop-1-en-2-amine

생성물 1

HCID 674109084-(3-Bromo-5-ethoxy-4-hydroxy-phenyl)-2-methyl-3-nitro-7-propyl-4,6,7,8-tetra-hydro-1H-quinolin-5-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-methyl-2-nitro-vinylamine (1 g), 5-propylcyclohexane-1,3-dione (1.61 g) and 3-bromo-5-ethoxy-4-hydroxy-benzaldehyde (2.57 g) in ethanol (50 ml) was stirred at reflux for 17 h. The reaction mixture was concentrated in vacuo. The residue was dissolved in dichloromethane. A precipitate formed, which was collected by filtration. The solid was chromatographed on silicagel in heptane/EtOAc (from 1/0 to 0/1) as eluent. Yield: 2.8 g. MS-ESI: [M+H]+=465.0/467.0

후처리

  1. temperatureat reflux for 17 h
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. dissolutionThe residue was dissolved in dichloromethane
  4. customA precipitate formed
  5. filtrationwhich was collected by filtration
  6. customThe solid was chromatographed on silicagel in heptane/EtOAc (from 1/0 to 0/1) as eluent

출처 및 근거

ORD 기록
ord-6614b13ee94444c9a27fb18c52faee20
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08017782B2

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