Ethyl vinyl ether → 1,1-Diphenyl-2-(1-ethenoxy)-hex-5-ene

HRID 909712

반응식

HRID 909712 반응식
[CH:1]([CH:14]1[CH2:19][C:18](=O)[CH:17]=[CH:16]O1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]([O-:24])(O)=O.[Na+].[CH:26](OCC)=C>[Hg](OC(C(F)(F)F)=O)OC(C(F)(F)F)=O>[C:2]1([CH:1]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]([O:24][CH:21]=[CH2:26])[CH2:19][CH2:18][CH:17]=[CH2:16])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8023Ethyl vinyl etherHCID 516892Sodium BicarbonateHCID 666308482-Benzhydryl-2H-pyran-4(3H)-one

생성물 1

HCID 666312581,1-Diphenyl-2-(1-ethenoxy)-hex-5-ene수율 66%

시약·촉매·용매 1

HCID 16685285Hg(TFA)2촉매

실험 절차

Into a mixture of 1,1-diphenyl-hex-5-en-2-ol 2 (7 g, 27.78 mmol) in ethyl vinyl ether (250 ml) was added Hg(OCOCF3)2 (2.37 g, 5.56 mmol) and was stirred overnight at room temperature. The reaction mixture was neutralized by addition of sat. aqueous NaHCO3. The organic phase was separated and the aqueous layer was extracted with ethyl ether, and dried over anhydrous Na2SO4. Removal of the solvent and purification by flash chromatography (Hexane/Ethyl Acetate 20:1) gave 1,1-diphenyl-2-(1-ethenoxy)-hex-5-ene 9 (5.1 g, 66%) as a liquid.

후처리

  1. customThe organic phase was separated
  2. extractionthe aqueous layer was extracted with ethyl ether
  3. dry with materialdried over anhydrous Na2SO4
  4. customRemoval of the solvent and purification by flash chromatography (Hexane/Ethyl Acetate 20:1)

출처 및 근거

ORD 기록
ord-a3c000d7e20b4c32aac048efa20c7954
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017791B2

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