Isoamylamine → N-(2,2-dimethoxyethyl)-3-methylbutan-1-amine

HRID 909879노트

반응식

HRID 909879 반응식
[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][NH2:5].[CH3:7][O:8][CH:9]([O:12][CH3:13])[CH:10]=O>CO.[Pd].O>[CH3:7][O:8][CH:9]([O:12][CH3:13])[CH2:10][NH:5][CH2:4][CH2:3][CH:2]([CH3:6])[CH3:1]

참가 물질

6

반응물 2

HCID 7894IsoamylamineHCID 162650Acetaldehyde, 2,2-dimethoxy-

생성물 1

HCID 59290479N-(2,2-dimethoxyethyl)-3-methylbutan-1-amine

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 3-methylbutan-1-amine (1.33 mL) and 2,2-dimethoxyacetaldehyde (1.73 mL) in MeOH (10 mL) was added to palladium on carbon (0.366 g) in water (0.5 mL) at 25° C. The mixture of was hydrogenated under 5 bar at 25° C. for 3 h. The reaction mixture was filtered and concentrated in vacuo to afford N-(2,2-dimethoxyethyl)-3-methylbutan-1-amine (1.8 g) as a liquid. 1H NMR (300 MHz, CDCl3) δ 4.47 (t, J=5.5 Hz, 1H), 3.39 (s, 6H), 2.74 (d, J=5.6 Hz, 2H), 2.65-2.59 (m, 2H), 1.62 (septet, J=6.7 Hz, 1H), 1.44-1.33 (m, 2H), 0.90 (d, J=6.7 Hz, 6H)

후처리

  1. additionThe mixture
  2. filtrationThe reaction mixture was filtered
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-813515c3a3c44c1ca6b93a1bc2702f8c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017602B2

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