Trimethylsilyldiazomethane → HCID 57419860, 화합물

HRID 909915

반응식

HRID 909915 반응식
[N+](=[CH:3][Si](C)(C)C)=[N-].[Br:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([OH:19])=[O:18])[CH:12]=[CH:13][C:14]=1[F:15]>C(OCC)C.ClCCl.CO>[Br:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([O:19][CH3:3])=[O:18])[CH:12]=[CH:13][C:14]=1[F:15]

참가 물질

6

반응물 2

HCID 167693TrimethylsilyldiazomethaneHCID 34163393-Bromo-4-fluorophenylacetic Acid

생성물 1

HCID 57419860HCID 57419860, 화합물

시약·촉매·용매 3

HCID 887Methanol용매HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

A solution of (diazomethyl)trimethylsilane (12.87 mL) in diethyl ether was added to an ice-batch cooled solution of 2-(3-bromo-4-fluorophenyl)acetic acid (3 g) in dichloromethane (20 mL) and methanol (5 mL). The mixture was stirred for 10 min. and concentrated in vacuo to give methyl 2-(3-bromo-4-fluorophenyl)acetate (3.20 g) that was

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-80960c89fff84353833007ac484a4262
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017602B2

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