Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → {[2-(Tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | tert-Butyl N-(2-bromoethyl)carbamate | HCID 4103526 | — |
| 반응물 | 4-Methylbenzene-1-sulfonic acid--benzyl N-methylglycinate (1/1) | HCID 12210899 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | {[2-(Tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester | HCID 59650730 | 38.2% |
반응 단계
500 mg (1.42 mmol) of sarcosine benzyl ester p-toluenesulfonate, 478 mg (2.13 mmol) of 2-(tert-butoxycarbonylamino)-ethyl bromide, and 0.25 mL (2.13 mmol) of diisopropyl-ethylamine were dissolved in methylene chloride (10 mL), and then stirred at room temperature for approximately three days. After completion of the reaction, the reaction solution was concentrated and the residue obtained was purified by silica gel column chromatography (ethyl acetate) to yield 175 mg (38%) of {[2-(tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester as a colorless viscous oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022047B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-8aa04aed8f674ce49ce09455ac4e5e70 |
| 출처 메모 | uspto-grants-2011_09 |