Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 3-tert-Butyldimethylsilyloxy Pregnenolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Pregnenolone | HCID 8955 | — |
| 반응물 | tert-Butyldimethylsilyl trifluoromethanesulphonate | HCID 123564 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-tert-Butyldimethylsilyloxy Pregnenolone | HCID 10884505 | — |
반응 단계
Imidazole (ImH) can be added to a solution of pregnenolone (compound 3, see Scheme 1) in anhydrous dimethylformamide (DMF). Tert-butyldimethylsilyltrifluoromethanesulfonate can then be added to the solution. The reaction product can be purified to obtain compound 4, 1-((3S,8S,9S,10R,13S,14S,17S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3-[(1,1-dimethylethyl)dimethylsilyloxy]-10,13-dimethyl-1H-cyclopenta[α]phenanthren-17-yl) ethanone, as shown in Scheme 2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022052B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-3f85b035e8f748f09b57c7667340d385 |
| 출처 메모 | uspto-grants-2011_09 |