Methyl 2-(3-phenoxypropenyl)benzoate → Methyl 2-(3-phenoxypropyl)benzoate

HRID 910166노트

반응식

HRID 910166 반응식
[O:1]([CH2:8][CH:9]=[CH:10][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([O:15][CH3:16])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[C].[Pd]>[O:1]([CH2:8][CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([O:15][CH3:16])=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 67414986Methyl 2-(3-phenoxypropenyl)benzoate

생성물 1

HCID 67413057Methyl 2-(3-phenoxypropyl)benzoate수율 55%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

The thus-obtained methyl 2-(3-phenoxypropenyl)benzoate (0.261 g, 0.972 mmol) was dissolved in methanol (6 ml), 10% palladium carbon (0.022 g) was added, and a hydrogenation reaction was performed at room temperature for 24 hr. The reaction mixture was filtered through celite, the filtrate was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to give methyl 2-(3-phenoxypropyl)benzoate (0.144 g, 0.533 mmol, yield 55%).

후처리

  1. customa hydrogenation reaction
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate)

출처 및 근거

ORD 기록
ord-81897f41f7554283830d72136a92baea
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022072B2

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