Ethyl 2-amino-4-phenylthiophene-3-carboxylate → Thieno(2,3-d)pyrimidin-4(1H)-one, 5-phenyl-

HRID 910180노트

반응식

HRID 910180 반응식
C([O:3][C:4]([C:6]1[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:9][S:8][C:7]=1[NH2:17])=O)C.C(O)(=O)C.[CH:22](N)=[NH:23]>C(O)C>[C:11]1([C:10]2[C:6]3[C:4](=[O:3])[NH:23][CH:22]=[N:17][C:7]=3[S:8][CH:9]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 73242Ethyl 2-amino-4-phenylthiophene-3-carboxylateHCID 160693Formamidine acetate

생성물 1

HCID 215639Thieno(2,3-d)pyrimidin-4(1H)-one, 5-phenyl-

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A stirred mixture of 2-amino-4-phenylthiophene-3-carboxylic acid ethyl ester (350.43 g, 1.535 mol), formamidine acetate (799.13 g, 7.7 mol) and ethanol (1500 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with a little cold ethanol, then crystallised from ethanol to give 5-Phenyl-3H-thieno[2,3-d]pyrimidin-4-one as a yellow solid which was used without further purification.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with a little cold ethanol
  5. customcrystallised from ethanol

출처 및 근거

ORD 기록
ord-6e912309763f44a5a8a3d8b62049b509
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022076B2

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