Water → HCID 22316930, 화합물

HRID 910220노트

반응식

HRID 910220 반응식
[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C1(C)C=CC(S([CH2:21][N:22]=C=O)(=O)=O)=CC=1.[C:26](=O)([O-])[O-].[K+].[K+].O>CO>[O:3]1[C:1]([C:4]2[CH:11]=[CH:10][C:7]([C:8](=[O:9])[CH3:26])=[CH:6][CH:5]=2)=[CH:2][N:22]=[CH:21]1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 5009465Benzaldehyde, 4-acetyl-HCID 117890781-Isocyanatomethanesulfonyl-4-methylbenzene

생성물 1

HCID 22316930HCID 22316930, 화합물수율 84%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-Acetylbenzaldehyde (2.96 g) and p-toluenesulfonylmethylisocyanate (4.69 g) were dissolved in methanol (200 mL). Potassium carbonate (3.32 g) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The solvent was evaporated, and the residue was purified through silica gel column chromatography (dichloromethane:methanol=100:1), followed by concentration under reduced pressure, to thereby yield the title compound (3.14 g).

후처리

  1. extractionfollowed by extraction with ethyl acetate
  2. customThe solvent was evaporated
  3. customthe residue was purified through silica gel column chromatography (dichloromethane:methanol=100:1)
  4. concentrationfollowed by concentration under reduced pressure

출처 및 근거

ORD 기록
ord-237d81c8fa0d45dd944acb723a4abb9f
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022075B2

반응 노트

불러오는 중…