2-Amino-5-bromopyrimidine → 5-[4-(6-Bromoimidazo[1,2-a]pyrimidin-2-yl)phenyl]-1,3-oxazole

HRID 910222노트

반응식

HRID 910222 반응식
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:23][CH:22]=[N:21][CH:20]=2)=[CH:15][CH:14]=1)=O>O1CCOCC1>[Br:8][C:5]1[CH:4]=[N:3][C:2]2[N:7]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[O:23][CH:22]=[N:21][CH:20]=4)=[CH:15][CH:14]=3)[N:1]=2)[CH:6]=1

참가 물질

4

반응물 2

HCID 2313102-Amino-5-bromopyrimidineHCID 866318862-Bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone

생성물 1

HCID 674055005-[4-(6-Bromoimidazo[1,2-a]pyrimidin-2-yl)phenyl]-1,3-oxazole수율 86.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2-Amino-5-bromopyrimidine (348 mg) and 2-bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone (532 mg) were suspended in 1,4-dioxane (20 mL), followed by refluxing under heating overnight. Immediately after refluxing, the reaction mixture was filtered without being cooled, followed by washing with heated 1,4-dioxane and drying, to thereby yield the title compound (587 mg).

후처리

  1. temperatureby refluxing
  2. temperatureunder heating overnight
  3. temperatureImmediately after refluxing
  4. filtrationthe reaction mixture was filtered
  5. temperaturewithout being cooled
  6. washby washing with heated 1,4-dioxane
  7. customdrying

출처 및 근거

ORD 기록
ord-7d9150ae60a447fe97a2c80da206e44c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022075B2

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