Acetic Acid → 2-Amino-5-bromobenzene-1-thiol

HRID 910229노트

반응식

HRID 910229 반응식
[OH-].[K+].NC1[S:5][C:6]2[CH:12]=[C:11]([Br:13])[CH:10]=[CH:9][C:7]=2[N:8]=1.C(O)(=O)C>O>[NH2:8][C:7]1[CH:9]=[CH:10][C:11]([Br:13])=[CH:12][C:6]=1[SH:5]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 14797Potassium HydroxideHCID 851492-Benzothiazolamine, 6-bromo-

생성물 1

HCID 12090452-Amino-5-bromobenzene-1-thiol수율 63.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Potassium hydroxide (39.6 g) was dissolved at 0° C. in water (80 mL), and 2-amino-6-bromobenzothiazole (6.87 g) was added to the solution, followed by refluxing under heating overnight. The mixture was returned to room temperature, and then neutralized with 5N aqueous acetic acid solution. The precipitated crystals were recovered through filtration, washed with water, and dried under reduced pressure with heating, followed by recrystallization from isopropyl ether, to thereby yield the title compound (3.87 g).

후처리

  1. temperatureby refluxing
  2. temperatureunder heating overnight
  3. customwas returned to room temperature
  4. filtrationThe precipitated crystals were recovered through filtration
  5. washwashed with water
  6. customdried under reduced pressure
  7. temperaturewith heating
  8. customfollowed by recrystallization from isopropyl ether

출처 및 근거

ORD 기록
ord-95dfb255a5eb49f497aad75ae6f1451b
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022075B2

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