Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 3-(4-Isopropyl-piperazin-1-yl)-phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1-(3-Hydroxyphenyl)piperazine | HCID 2736597 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(4-Isopropyl-piperazin-1-yl)-phenol | HCID 58499480 | 59.9% |
반응 단계
Acetone (1.95 g) and NaBH(OAc)3 (7.12 g) were added to a solution of 3-piperazin-1-yl-phenol (2.00 g) in THF (40 ml), and the mixture was stirred at room temperature for 18 hours. Saturated aqueous sodium bicarbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and filtered to give the titled compound (1.48 g, colorless powder).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022091B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-f0cc949488174e2aa69b178879108f42 |
| 출처 메모 | uspto-grants-2011_09 |