Piperazine → 2-Piperazin-1-yl-4-thiophen-2-yl-pyrimidine
반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[CH:5]=[CH:4][N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>CC(O)C>[N:13]1([C:2]2[N:7]=[C:6]([C:8]3[S:9][CH:10]=[CH:11][CH:12]=3)[CH:5]=[CH:4][N:3]=2)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1참가 물질
4
반응 조건
- 온도
- 160 °C
실험 절차
To a microwave tube was added 2-chloro-4-thiophen-2-yl-pyrimidine (20 mg, 0.1 mmol), piperazine (26 mg, 0.3 mmol) and 2-propanol (0.6 mL). The resulting mixture was heated at 160° C. for 60 minutes using the microwave instrument. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.
후처리
- extractionThe resulting mixture was extracted with EtOAc
- customThe organic layer was dried
- concentrationconcentrated
- customthe residue was purified by preparative TLC (hexanes/EtOAc)
출처 및 근거
- ORD 기록
- ord-ffc125d27a11461190d69eedfd15f499
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08022209B2
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