DL-Homoserine → Methyl homoserinate hydrochloride

HRID 910726

반응식

HRID 910726 반응식
[NH2:1][CH:2]([C:6]([OH:8])=[O:7])[CH2:3][CH2:4][OH:5].[CH3:9][Si]([Cl:13])(C)C>CO>[ClH:13].[CH3:9][O:7][C:6](=[O:8])[CH:2]([NH2:1])[CH2:3][CH2:4][OH:5]

참가 물질

4

반응물 2

HCID 779DL-HomoserineHCID 6397Chlorotrimethylsilane

생성물 1

HCID 53350305Methyl homoserinate hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of DL-homoserine (1.00 g, 8.39 mmol) in methanol (40 mL) was placed in an ice bath. Trimethylsilyl chloride (2.34 mL, 18.5 mmol) was added dropwise via syringe. The reaction mixture gradually became homogenous and was further stirred at rt for 14 h, concentrated by rotary evaporation, and further dried under high vacuum. The crude oil thus obtained was used for the next step without further purification. 1H NMR (300 MHz, CD3OD) δ 2.00-2.24 (m, 2H), 3.70-3.80 (m, 2H), 3.85 (s, 3H), 4.12-4.22 (m, 1H). m/z (ESI) 134 [C5H11NO3+H]+.

후처리

  1. customwas placed in an ice bath
  2. concentrationconcentrated by rotary evaporation
  3. customfurther dried under high vacuum
  4. customThe crude oil thus obtained
  5. customwas used for the next step without further purification

출처 및 근거

ORD 기록
ord-342e9a63bce9417b9949ca747ce99454
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022210B2

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