3-Bromo-5-ethoxy-4-hydroxybenzaldehyde → 2-(2-Bromo-6-ethoxy-4-formyl-phenoxymethyl)-furan-3-carboxylic acid methyl ester

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:11][CH2:12][CH3:13])[C:9]=1[OH:10])[CH:5]=[O:6].[CH3:14][O:15][C:16]([C:18]1[CH:22]=[CH:21][O:20][C:19]=1[CH2:23]Br)=[O:17]>>[CH3:14][O:15][C:16]([C:18]1[CH:22]=[CH:21][O:20][C:19]=1[CH2:23][O:10][C:9]1[C:8]([O:11][CH2:12][CH3:13])=[CH:7][C:4]([CH:5]=[O:6])=[CH:3][C:2]=1[Br:1])=[O:17]

참가 물질

반응물 2

HCID 6124963-Bromo-5-ethoxy-4-hydroxybenzaldehyde

HCID 2736827Methyl 2-(Bromomethyl)-3-Furoate

생성물 1

HCID 866244092-(2-Bromo-6-ethoxy-4-formyl-phenoxymethyl)-furan-3-carboxylic acid methyl ester

실험 절차

Alkylation of 3-bromo-5-ethoxy-4-hydroxy benzaldehyde (123 mg) with 2-bromomethyl-furan-3-carboxylic acid methyl ester (109 mg) was performed according to the method described in example 1a. Yield: 191 mg. MS-ESI: [M+H]+=383/385

출처 및 근거

ORD 기록: ord-343dc2bb77fa45b8846f2709dd2737e3
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08022218B2

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