Zytron → HCID 86624412, 화합물

HRID 910761

반응식

HRID 910761 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH2:11])[CH3:10])=[CH:5][CH:4]=1.CC(NP(OC1C=CC(Cl)=CC=1Cl)(OC)=S)C.[CH2:29]=[C:30]1[O:33][C:32](=[O:34])[CH2:31]1>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:32](=[O:34])[CH2:31][C:30](=[O:33])[CH3:29])[CH3:10])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 9299ZytronHCID 12661DiketeneHCID 793467(S)-1-(4-Methoxyphenyl)ethylamine

생성물 1

HCID 86624412HCID 86624412, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
20 °C

실험 절차

To a solution of (S)-1-(4-methoxy-phenyl)-ethylamine (25 g) in dichloromethane (60 mL) was added TEA (20 g) and DMPA (200 mg). Then a solution of 4-methylene-oxetan-2-one (16.7 g) in dichloromethane (60 ml) was added over a period of 30 minutes and then stirred at 20° C. for 18 h. The mixture was washed with 1M HCl, aq. NaHCO3 and aq. NaCl. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.

후처리

  1. washThe mixture was washed with 1M HCl, aq. NaHCO3 and aq. NaCl
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fdd2daeea4e04186afc19c09f929978c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022218B2

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