Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenol → 4-Chloro-2-phenoxyaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Chloro-2-fluoro-1-nitrobenzene | HCID 69691 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Chloro-2-phenoxyaniline | HCID 246563 | 143.8% |
반응 단계
2-Fluoro-4-chloro-nitrobenzene (0.50 g), phenol (0.27 g) and potassium carbonate (0.40 g) in dry DMSO (10 ml) were stirred at RT for 2 h. The mixture was diluted with water, extracted with diethylether, dried and evaporated under reduced pressure to give a yellow oil (0.90 g). The oil was dissolved in glacial acetic acid (20 ml) and treated with reduced iron powder (0.90 g). The mixture was vigorously stirred at RT for 2 h, filtered through celite, washed with DCM and the filtrate evaporated under reduced pressure, yield 0.9 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022248B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-7b410098b22642ddb566b5ebb181f893 |
| 출처 메모 | uspto-grants-2011_09 |