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Water → 4-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]thio}-1-nitrobenzene

HRID 910834
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HRID 910834 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[SH:13].C(=O)([O-])[O-].[K+].[K+].F[C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=1[N+:28]([O-:30])=[O:29].O>CN(C=O)C>[Cl:27][C:25]1[CH:26]=[CH:21][C:22]([N+:28]([O-:30])=[O:29])=[C:23]([S:13][C:3]2[CH:4]=[CH:5][C:6]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])=[CH:7][C:2]=2[Cl:1])[CH:24]=1
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참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 696914-Chloro-2-fluoro-1-nitrobenzeneHCID 673906392-Chloro-4-(ethylsulfonyl)benzenethiol

생성물 1

HCID 673916204-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]thio}-1-nitrobenzene

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A mixture of the product from step (i) (1.60 g), potassium carbonate (0.934 g) and 2-fluoro-4-chloro-nitrobenzene (1.18 g) in DMF (20 ml) was stirred at RT overnight. Water (200 ml) was added and the mixture extracted with ethyl acetate. The organics were dried, evaporated under reduced and the residue purified by chromatography on silica eluting with isohexane/diethylether 4:1, yield 0.80 g.

후처리

  1. extractionthe mixture extracted with ethyl acetate
  2. customThe organics were dried
  3. customevaporated
  4. customthe residue purified by chromatography on silica eluting with isohexane/diethylether 4:1, yield 0.80 g

출처 및 근거

ORD 기록
ord-270b8f60c6134d7aa5ec7dda45b671f4
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08022248B2

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