Dimethylformamide → 4-Chloro-2-(methylthio)benzaldehyde
반응식
[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1C=O.[CH3:11][S-:12].[Na+].CN([CH:17]=[O:18])C>O>[Cl:1][C:2]1[CH:3]=[CH:6][C:7]([CH:17]=[O:18])=[C:8]([S:12][CH3:11])[CH:9]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
The subtitle compound was prepared by using 2-chloro-4-fluorobenzaldehyde (1.16 g) in dry DMF (20 ml). The mixture was treated with sodium thiomethoxide (0.52 g) and heated to 50° C. for 2 hours. The mixture was diluted with water, extracted with ethyl acetate, dried and concentrated under reduced pressure to give a solid. The residue was purified by chromatography on silica eluting with isohexane/diethylether 2:1 to give a white solid, yield 0.70 g.
후처리
- extractionextracted with ethyl acetate
- customdried
- concentrationconcentrated under reduced pressure
- customto give a solid
- customThe residue was purified by chromatography on silica eluting with isohexane/diethylether 2:1
- customto give a white solid, yield 0.70 g
출처 및 근거
- ORD 기록
- ord-4cd3fac65bf5437cba65cda14e5e38d1
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08022248B2
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