Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Phosphate, Tribasic → HCID 24826661, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 2-Amino-4-methylthiazole | HCID 74143 | — |
| 반응물 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 반응물 | 2-Chloro-4-(2,6-dimethylphenoxy)pyridine | HCID 86634736 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 생성물 | HCID 24826661 | HCID 24826661 | 44% |
반응 단계
Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.244 g, 2.14 mmol), 2-chloro-4-(2,6-dimethylphenoxy)pyridine (0.500 g, 2.14 mmol), potassium phosphate (0.500 g, 2.35 mmol), Pd2(dba)3 (0.098 g, 0.107 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.062 g, 0.107 mmol) were reacted to provide N-(4-(2,6-dimethylphenoxy)pyridin-2-yl)-4-methylthiazol-2-amine (0.290 g, 44% yield). 1H NMR (d6-DMSO) δ 10.93 (s, 1H), 8.13 (d, 1H), 7.15-7.22 (m, 3H), 6.50 (s, 1H), 6.40 (d, 1H), 6.39 (s, 1H), 2.19 (s, 3H), 2.08 (s, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022222B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-d7431034cea649d9bd06fcef084ef778 |
| 출처 메모 | uspto-grants-2011_09 |