Bromine → Ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate

HRID 911035노트

반응식

HRID 911035 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:10]=[C:11]([CH:17]=[CH:18][C:19]=2[Cl:20])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:4][N:3]=1.[Br:21]Br>C(O)(=O)C>[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:10]=[C:11]([CH:17]=[CH:18][C:19]=2[Cl:20])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:5]([Br:21])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 66617829Ethyl 3-(2-aminopyridin-4-yloxy)-4-chlorobenzoate

생성물 1

HCID 66617810Ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate수율 61.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A flask was charged with ethyl 3-(2-aminopyridin-4-yloxy)-4-chlorobenzoate (5.50 g, 18.8 mmol) and acetic acid (50 mL), and bromine (0.943 ml, 18.4 mmol) was added. The reaction was stirred at ambient temperature for 30 minutes and then concentrated. The residue was purified by silica gel column chromatography, eluting with 20%-35% ethyl acetate in hexanes to give the desired product (4.20 g, 58.9% yield) as light yellow solid.

후처리

  1. additionwas added
  2. concentrationconcentrated
  3. customThe residue was purified by silica gel column chromatography
  4. washeluting with 20%-35% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-acb1015a38cd4fb2a8527bc7d186e04d
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022222B2

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