홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → ethyl 3-(5-bromo-2-(4-phenethylthiazol-2-ylamino)-Pyridin-4-yloxy)-4-chlorobenzoate

HRID 911038
노트
인쇄 미리보기

반응식

HRID 911038 반응식
[Br:1][C:2]1[C:3]([O:12][C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][C:23]=2[Cl:24])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:4][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[N:6][CH:7]=1.Br[CH2:26][C:27](=O)[CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.C(N(CC)CC)C>C(O)C>[Br:1][C:2]1[C:3]([O:12][C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][C:23]=2[Cl:24])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:4][C:5]([NH:8][C:9]2[S:10][CH:26]=[C:27]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[N:11]=2)=[N:6][CH:7]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 126080271-Bromo-4-phenylbutan-2-oneHCID 86634759Ethyl 3-(5-bromo-2-thioureidopyridin-4-yloxy)-4-chlorobenzoate

생성물 1

HCID 57898948ethyl 3-(5-bromo-2-(4-phenethylthiazol-2-ylamino)-Pyridin-4-yloxy)-4-chlorobenzoate수율 96.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A flask was charged with ethyl 3-(5-bromo-2-thioureidopyridin-4-yloxy)-4-chlorobenzoate (0.200 g, 0.464 mmol), 1-bromo-4-phenylbutan-2-one (0.105 g, 0.464 mmol) and triethylamine (0.0470 g, 0.464 mmol). Ethanol (5 mL) was added and the reaction was heated at 70° C. for 6 hours, and then concentrated to provide ethyl the desired product (0.250 g, 95 yield) as white solid. LC/MS (apci) M+2H: 560 (100%).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1d01b8808b54441bbb5743dd3cf3c68f
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08022222B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트