Thiophosgene → HCID 83290701, 화합물
반응식
[C:1](Cl)(Cl)=[S:2].[Cl:5][C:6]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8]([CH3:13])[N:7]=1.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[Cl:5][C:6]1[C:11]([N:12]=[C:1]=[S:2])=[CH:10][CH:9]=[C:8]([CH3:13])[N:7]=1참가 물질
5
실험 절차
A solution of thiophosgene (3.871 g, 33.66 mmol) in dichloromethane (10 mL) was added to a mixture of 2-chloro-6-methylpyridin-3-amine (4.00 g, 28.05 mmol) and sodium carbonate (5.947 g, 56.11 mmol) in dichloromethane (200 mL). The reaction was stirred overnight at ambient temperature, then washed with water, brine, dried, and concentrated to afford the desired product (5.2 g, 100.4% yield) as a tan powder.
후처리
- washwashed with water, brine
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e515da91033240fd815f2057ec29fb8d
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08022222B2
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