Trifluoroacetic acid → (2R)-1-(benzyloxy)propan-2-amine

HRID 911246노트

반응식

HRID 911246 반응식
[CH2:1]([O:8][CH2:9][C@H:10]([NH:12]C(OC(C)(C)C)=O)[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([O:8][CH2:9][C@H:10]([NH2:12])[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 11254115(R)-3-Benzyloxy-2-(tert-butoxycarbonylamino)-propane

생성물 1

HCID 59977290(2R)-1-(benzyloxy)propan-2-amine수율 89%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

Dissolve (R)-3-benzyloxy-2-(tert-butoxycarbonylamino)-propane (800 mg, 3 mmol) in DCM (10 mL), add trifluoroacetic acid (5 mL), and stir at 0° C. for 20 min. Evaporate and purify by SCX chromatography to give the title compound as a colorless oil (440 mg, 89%). MS (ES+) m/z: 166 (M+H)+.

후처리

  1. customEvaporate
  2. custompurify by SCX chromatography

출처 및 근거

ORD 기록
ord-05188244d3c44fbba9d7d4d7656c25fd
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022062B2

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