Trifluoroacetic acid → (2R)-1-Phenoxy-2-propanamine
반응식
C(OC([NH:8][C@@H:9]([CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:10])=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:10][C@@H:9]([NH2:8])[CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
Dissolve (R)-2-(tert-butoxycarbonylamino)-3-phenoxy-propane (340 mg, 1.35 mmol) in DCM (80 mL), add trifluoroacetic acid (35 mL), and stir at 0° C. for 2 h. Evaporate and purify by SCX chromatography to give the title compound as a colorless oil (186 mg, 91%). MS (ES+) m/z: 151 (M+H)+.
후처리
- customEvaporate
- custompurify by SCX chromatography
출처 및 근거
- ORD 기록
- ord-ddad170496db43ab8c454e8464ed1a9e
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08022062B2
반응 노트
불러오는 중…