Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → Methyl benzo[d]thiazole-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Benzothiazole-6-carboxylic acid | HCID 601670 | — |
| 반응물 | N-Methyl-N'-nitro-N-nitrosoguanidine | HCID 135436526 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl benzo[d]thiazole-6-carboxylate | HCID 595763 | 102% |
반응 단계
Add 1-methyl-3-nitro-1-nitrosoguanidine (5.0 g, 33.9 mmol) to a mixture of diethyl ether (20 mL) and 1N aqueous NaOH (20 mL) at ambient temperature. Separate the organic layer and add it slowly to a solution of benzothiazole-6-carboxylic acid (1.0 g, 5.58 mmol) in THF (50 mL) at 0° C. Evaporate the solvent to obtain the desired intermediate as a yellow solid (1.1 g, 100%). MS (ES+) m/z: 194 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022062B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-2558141ffd684e63b19fc19e482332db |
| 출처 메모 | uspto-grants-2011_09 |