Benzofuran-4-carbonitrile → (1-Benzofuran-4-yl)methanamine
반응식
[O:1]1[C:5]2=[CH:6][CH:7]=[CH:8][C:9]([C:10]#[N:11])=[C:4]2[CH:3]=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[NH2:11][CH2:10][C:9]1[C:4]2[CH:3]=[CH:2][O:1][C:5]=2[CH:6]=[CH:7][CH:8]=1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
Dissolve benzofuran-4-carbonitrile (0.3 g, 1.96 mmol) in anhydrous THF (5 mL) and add slowly to 1M lithium aluminum hydride in THF (3.91 mL, 3.91 mmol) at ambient temperature. Heat the reaction mixture at 50° C. for 5 h and cool to ambient temperature. Quench the reaction mixture with water until a granular precipitate starts to form and filter through a pad of Celite®. Evaporate the solvent and purify by SCX chromatography to obtain the title compound as a brown oil (0.4 g, 79%). GC-MS m/z: 147 (M+).
후처리
- temperaturecool to ambient temperature
- customQuench the reaction mixture with water until a granular precipitate
- customto form
- filtrationfilter through a pad of Celite®
- customEvaporate the solvent
- custompurify by SCX chromatography
출처 및 근거
- ORD 기록
- ord-e3b82ddac2fb4155a382c270af28d765
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08022062B2
반응 노트
불러오는 중…