Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → 1-(6-Methylpyridin-2-yl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 6-Methyl-2-pyridinecarboxaldehyde | HCID 70737 | — |
| 반응물 | HCID 178418573 | HCID 178418573 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(6-Methylpyridin-2-yl)ethanol | HCID 353138 | — |
반응 단계
To 6-methylpyridine-2-carboxaldehyde (2.0 g, 16.5 mmol) in dry THF (55 mL) at 0° C. under nitrogen, add a solution of 3M methyl magnesium bromide in ether (6.0 mL, 18.0 mmol) dropwise with stirring. After 1 h at 0° C., quench with saturated aqueous NH4Cl, extract three times with EtOAc, dry over anhydrous Na2SO4 and concentrate in vacuo to give the desired intermediate (crude, 2.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022062B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-e4e089cff6174624942de9363c4cc38b |
| 출처 메모 | uspto-grants-2011_09 |