Thionyl Chloride → (+/-)-2-(1-Chloroethyl)-6-methylpyridine hydrochloride

HRID 911433

반응식

HRID 911433 반응식
O[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[N:5]=1)[CH3:3].S(Cl)([Cl:13])=O>C(Cl)Cl>[ClH:13].[Cl:13][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[N:5]=1)[CH3:3]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 3531381-(6-Methylpyridin-2-yl)ethanol

생성물 1

HCID 66706611(+/-)-2-(1-Chloroethyl)-6-methylpyridine hydrochloride수율 85%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the crude 2-(1-hydroxyethyl)-6-methylpyridine (1.6 g, 11.7 mmol) in dry DCM (15 mL) add with stirring thionyl chloride (2.0 mL, 27 mmol) and continue stirring overnight Concentrate in vacuo, azeotrope three times with dry chloroform and dry under high vacuum to provide the title compound as a tan solid (1.9 g, 85%). MS (APCI+) m/z 156 (M+H)+.

후처리

  1. concentrationConcentrate in vacuo
  2. customdry under high vacuum

출처 및 근거

ORD 기록
ord-a65254b7cd5c4aea8e7be1512f5c8d13
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022062B2

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