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Triethylamine → HCID 86661654, 화합물

HRID 911449
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HRID 911449 반응식
[F:1][C:2]([F:12])([F:11])[C:3]([C:7]([F:10])([F:9])[F:8])([CH3:6])[CH2:4][OH:5].C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl.O>[F:1][C:2]([F:11])([F:12])[C:3]([CH3:6])([C:7]([F:9])([F:8])[F:10])[CH2:4][O:5][S:21]([CH3:20])(=[O:23])=[O:22]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27361853,3,3-Trifluoro-2-methyl-2-(trifluoromethyl)propan-1-ol

생성물 1

HCID 86661654HCID 86661654, 화합물수율 101.7%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

To 2,2-bis(trifluoromethyl)propanol (4.34 g, 22.1 mmol) in DCM (100 mL) at 0° C. add with stirring triethylamine (6.2 mL, 44 mmol) followed by methanesulfonyl chloride (2.6 mL, 33 mmol). After 15 min at 0° C. dilute with water and extract three times with EtOAc. Dry over anhydrous Na2SO4 and concentrate in vacuo to give the crude desired intermediate as a yellow oil (6.16 g, 100%).

후처리

  1. extractionextract three times with EtOAc
  2. dry with materialDry over anhydrous Na2SO4
  3. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-14d2939c140f4b5e808ef25b54d4d027
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08022062B2

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